Antibiotics now ineffective for common childhood infections: Lancet
IANS 01 November 2023
High rates of antibiotic resistance have rendered the drugs used to treat common infections in children and babies, ineffective, according to an alarming study published in Lancet South East Asia on Tuesday.
The University of Sydney led study found many antibiotics recommended by the World Health Organization (WHO) had less than 50 per cent effectiveness in treating childhood infections such as pneumonia, sepsis (bloodstream infections) and meningitis.  
The most seriously affected regions are in South-East Asia and the Pacific, including neighbouring Indonesia and the Philippines, where thousands of unnecessary deaths in children resulting from antibiotic resistance occur each year.
Lead author Phoebe Williams from the University's School of Public Health, said there are increasing cases of multidrug-resistant bacterial infections in children around the world.
AMR is more problematic for children than adults, as new antibiotics are less likely to be trialled on, and made available to, children.
Dr Williams said the study should be a wake-up call for the whole world.
"The burden of antimicrobial resistance is on our doorstep," she said.
"Antibiotic resistance is rising more rapidly than we realise. We urgently need new solutions to stop invasive multidrug-resistant infections and the needless deaths of thousands of children each year."
The WHO has declared antimicrobial resistance (AMR) is one of the top 10 global public health threats facing humanity. In newborns, an estimated three million cases of sepsis occur globally each year, with up to 570,000 deaths: many of these are due to lack of effective antibiotics to treat resistant bacteria.
The research reveals the urgent need for global antibiotic guidelines to be updated, to reflect the rapidly evolving rates of AMR. The most recent guideline from the WHO was published in 2013.
Further, the study found one antibiotic in particular, ceftriaxone, was likely to be effective in treating only one in three cases of sepsis or meningitis in newborn babies. 
Another antibiotic, gentamicin, was found likely to be effective in treating fewer than half of all sepsis and meningitis cases in children.
Gentamicin is commonly prescribed alongside aminopenicillins, which the study showed also has low effectiveness in combating bloodstream infections in babies and children.
The study analysed 6,648 bacterial isolates from 11 countries across 86 publications to review antibiotic susceptibility for common bacteria causing childhood infections.
Wiliams said the best way to tackle antibiotic resistance in childhood infections is to make funding to investigate new antibiotic treatments for children and newborns a priority.
"Antibiotic clinical focus on adults and too often children and newborns are left out. That means we have very limited options and data for new treatments."
Disclaimer: Information, facts or opinions expressed in this news article are presented as sourced from IANS and do not reflect views of Moneylife and hence Moneylife is not responsible or liable for the same. As a source and news provider, IANS is responsible for accuracy, completeness, suitability and validity of any information in this article.
Even More Reasons To Add Fibre to Your Diet
Akshay Naik 27 October 2023
The benefits of insoluble fibre, for bowel regularity and overall health, have been known and highly praised by health professionals. New research now suggests even more reasons to prioritise fibre in our regular...
US report finds 'concerning' levels of lead, cadmium in chocolates; top trade body responds
IANS 26 October 2023
After US-based non-profit group Consumer Reports alleged it detected a "concerning" amount of lead and cadmium in popular chocolate brands during tests, the National Confectioners Association (NCA) has said that "chocolate and cocoa...
Calorie Restriction Builds Strong Muscle and Stimulates Healthy Ageing Genes
Akshay Naik 20 October 2023
Investigating the biological mechanisms brought about by calorie restriction, a new study from researchers at the US National Institutes of Health (NIH) has found that a moderate reduction in calorie intake can improve muscle health...
Resistant Starch May Help Lower Risk of Fatty Liver Disease, Finds Study
Akshay Naik 11 October 2023
Resistant starch is a non-digestible fibre that ferments in the large intestine. Consumption of such starch has been previously shown to have a positive effect on metabolism, in animal studies. New research now indicates that...
Free Helpline
Legal Credit